Gw501516: Synonyms: Cardarine;2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid;Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid;2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid;GSK-516 CAS No: 317318-70-0 Molecular Formular: C21H18F3NO3S2 Molecular Weight: 453.498 Appearance: White fine powder Lossing On Drying:≤0.5% Assay:≥98.0% Ignition Residue:≤0.1% Heavy Metal:≤20PPm Standard: Enterprise standard
Usage: An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
White Crystalline Powder
White Crystalline Powder
Loss On Drying
Residue On Ignition
The specification conform with enterprise standard.
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.
It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies.
1.GW501516 is a selective agonist (activator) of the PPAR delta receptor. PPARδ with PPARα and PPARγ with & gt; 1000-fold selectivity showed high affinity (Ki = 1 nM) and titer (EC50 = 1 nM).
2.In rats, the combination of GW501516 and PPAR delta recruited the auxiliary activator PGC-1a. PPARδ / coactivator complex regulates the expression of proteins involved in energy consumption. In addition, in rats treated with GW501516, the increase in fatty acid metabolism and diet-induced obesity and type II diabetes were observed in skeletal muscle. In obese rhesus monkeys, GW501516 increased high density lipoprotein (HDL) and reduced very low density lipoprotein (VLDL). PPAR delta agonists increase the HDL mechanism as appears to be the result of increased expression of cholesterol transporter ABCA1.
3.Athletes can use the GW501516 as a sensitizing performance-enhancing drug that has not yet been tested by regulatory or standard testing. One of the leading researchers in the study emphasizes endurance research is to conduct urine tests to detect drugs and provide them to the IOC.
Medical Use Cardarine was primarily developed to treat obesity, diabetes, lipid strain, and heart health problems. As a matter of fact, those who run blood work will notice that cardarine will magically aid with lipid strain, and their cholesterol levels will improve substantially.
Endurance athletes may increase exercise endurance by stacking this PPAR with the AMP analog drug AICAR, or run cardarine solo. As a result, they will have a greater ability to reach higher RPM's during their runs without hitting the maximum heart rate. Regarding the bodybuilders, cardarine can benefit them in two ways: 1. Its ability to burn fat 2. Its ability to help the athlete have harder and longer workouts, without getting winded.
In terms of obesity, cardarine reverses metabolic abnormalities in obese and pre-diabetic men by stimulating fatty acid oxidation. That is, it burns fat by increasing glucose uptake in skeletal muscle tissue, which changes the body's metabolism to burn fat for energy instead of muscle or carbs. Incredibly, it does all this without dropping blood sugar levels like diabetic drugs do. Interestingly, when mice were given a high fat diet, they still lost fat, which proves that cardarine prevents obesity.
Side Effects: 1.Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug.
2.GW501516 has not only been tested in healthy subjects, but also those with simulated "real life" habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long term ramifications, but no research has been published stating otherwise. This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases.
3. 10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host's sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be
4. GW501516 has been tested for a 2 year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW501516 was created for LONG TERM usage, so there is no reason why it shouldn't be used that way.
5. Half life is between 16-24 hours and should be take at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose.
6. No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used.Highly recommended to use with a ketogenic diet.Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions.
How to proceed an order?
First: Please let me know the itmes you are looking for, quantity, and the destination country .Second: You confirm all details, and offer us purchasing order;
Third: We send the detail price of our product and offer suitable shipping method reference.
Forth: You confirm the order and pay money 100% in advance and send us detail address.
Fifth: We arrange the shipment according to your requirements.
Sixth: We offer after-sales service after you receive parcel;
Our Advantages: 1. Packing Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email. 2. Quality Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell. 3. Delivery We can pack your powders within 48 hours after your payment, and corresponding picture of your powders' parcel will be sent to you. 4. Price Best prices you're sure to be satisfied, the more you buy, the more competitive prices you get. 5. Payment T/T, paypal, Money Gram,Bitcoin, Western Union.